Understand compatibility and the effects of alcohol and antibiotics

Antibiotic therapy helps to get rid of infections of different etiology. However, this method of treatment imposes certain restrictions on their way of life: taboo many foods, and even sunbathing, as some antibacterial drugs increases the body's sensitivity to UV radiation.
Patients is not always possible to strictly follow the doctor's recommendations, especially regarding the consumption of alcoholic beverages. What happens if you drink alcohol when taking antibiotics, and how dangerous alcohol with such a mix?

alcohol and antibiotics

Can I drink alcohol when taking antibiotics?

The medical community since the discovery of penicillin was interested in the interaction of alcohol and antibiotics. The first large-scale study aimed at identifying a compatibility of spirits and antibiotic drugs, date from the end of the twentieth century.

Laboratory tests conducted on animals and volunteers have shown that alcohol has no significant effect on many antibiotics. The latter had maintained its performance indicators in both groups: as in the experimental and in the control. It was not revealed significant abnormalities in the mechanisms of absorption, speed of onset of pharmacological effect, its intensity and duration.

However, there are antibiotics that are absolutely inconveniens with alcohol. For example, some of serious drugs and alcohol can cause seizures, even death.

What is the main danger of this combination?

The main side effects of combination antibiotic therapy and intake of alcoholic beverages appear disulfiramopodobnaya reaction, drug hepatitis and toxic lesions of the Central nervous system.

  1. Preventing the metabolism of ethanol, antibiotics contribute to the accumulation in the body of acetaldehyde. Increasing intoxication manifested dyspeptic disorders and respiratory failure. The patient's condition with the development of disulfiramopodobnaya reaction is enhanced by the fact that frequent vomiting leads to dehydration (increasing toxicity) and the electrolyte imbalance (disturbance of heart rhythm, increased CNS depression). The most dangerous frequency of such complications cephalosporins and derivatives of nitroimidazole.
  2. Toxic liver damage occurs due to violation of the metabolism of antibiotics, because of the conflict of drugs and ethanol for binding with the enzyme cytochrome P450 2C9. This enzyme is responsible for the excretion of metabolites of alcohol and some drugs (erythromycin, ketoconazole, voriconazole, etc.). The conflict appears only ethyl alcohol, or the metabolites of drugs accumulate in the body causing severe toxicity and liver damage.
  3. Toxic Central nervous system depression is due to a combination of the sedative effect of alcohol and some antibiotics. It most often develops in older people and debilitated patients.
antibiotics and wine

Can I drink wine with antibiotics? Or spirits?

Western experts have estimated the amount of alcohol that can be taken during antibiotic therapy. The Department of health advises that men drink a maximum of 40 ml of ethanol, and women – 30 ml. This amount of pure alcohol contains approximately 100 ml of vodka or brandy (the fortress is forty percent), and 400 ml of wine (the fortress is twelve percent).

The liver of a healthy person will not suffer from 200 ml of strong alcohol, but the dose affects brain activity and Central nervous system. The fact that some antibiotics are able to cross the blood-brain barrier. Alcohol damages the dendrites of the cerebellum and disrupts communication between neurons and even joined the antimicrobial drugs that affect the brain, blood vessels and provoke vestibular disorders.

High concentrations of alcohol in combination with an antibiotic lead to oppression of inhibitory processes in the cerebral cortex, increasing the toxic effects on the nervous system, polyneuropathies are inflammatory diseases of the peripheral nerves, etc.

Spirits negate the effect of the antibiotic and increase the inhibition of the enzymatic activity of the flora of the gastrointestinal tract, leading to dysbiosis. After repeated ingestion of vodka and cognac activate inflammatory processes, impairing the overall health of the patient. Dehydration occurs the body, postponing a full recovery and exstirpatione of the pathogen.

Can I drink beer while taking antibiotics?

Beer is a soft drink, so the temptation of its use during the period of antibiotic therapy is so great. Small quantities of beer do not cause serious harm. The danger is that people rarely restricted to dimidium-liter bottle, drink much more. When you use 600-700 ml strong beer in the body gets about 40-50 ml of pure alcohol.

Ethyl alcohol, even in small amounts is a poison, destructive acting on the cells of the body. It burns the mucous membranes of the digestive tract, provokes spasmodic contraction of the blood vessels and causes changes in blood pressure.

Antimicrobial agents destroy not only pathogenic flora, but also endogenous. This imbalance becomes the cause of dysbiosis. Changed the composition of the microorganisms inhabiting the gut — is one of the contraindications to the use of beer, which will only worsen the disease.

antibiotics and beer

The combination of drugs of this pharmacological group and beer is dangerous because in an alcoholic beverage contains carbon dioxide (carbon dioxide). This colorless gas accelerates the absorption of toxic substances, and the rate of chemical reactions increases.

Ethyl continens drink inactivates drugs, and prescribed dosage are not enough to achieve a therapeutic effect. Due to the lack of bacteriostatic or bactericidal action of the pathogenic microorganisms is formed antibiotic resistentia.

Non-alcoholic beer and antibiotics: compatibility and effects

Non-alcoholic beer actually contains from 0.2 to 1 % pure ethanol. However, experts are wary of such symbiosis as patients compensate for a small percentage of alcohol large quantity of alcohol.

Low-alcohol beverage is a diuretic, which increases the nephrotoxicity of antimicrobial means. Alcohol, which entered into chemical reaction with the active pharmaceutical substance, can cause the following complications:

  • headache;
  • dyspeptic disorders;
  • weakness, lethargy and malaise.

Antibiotics and alcohol: the effects

The incompatibility of alcohol and antibiotics can lead to the development disulfiramopodobnaya reaction which reduces the metabolism of ethanol. In the body accumulates acetaldehyde, reinforcing the intoxication of the organism. Vomiting unpleasant feeling of discomfort in the epigastrium, shortness of breath, increased blood pressure and tachycardia. The same effect has the drug disulfiram used in the treatment of alcoholism.

During simultaneous administration of antibiotics and ethanol violated the metabolic processes. The fact that ethanol and pharmacological agents are decomposed under the influence of the same enzymes (enzymes). When alcohol oxidative biotransformation of antibiotics slows down, and enzymes focus on body detoxification from alcohol.

Alcohol is combined with antibiotics has a powerful sedative effect.

Depression of the Central nervous system and the reduction of concentration dangerous for the elderly, for those who drives a vehicle and is engaged in potentially hazardous activities, quaedam a high speed of psychomotor reactions.

We should also highlight the consequences of consuming beer during antibiotic therapy:

  • allergic reactions (anaphylaxis, skin rashes, fever urticae, the reaction Arisa-Herxheimer, bronchial asthma of allergic Genesis);
  • ulcerative lesions;
  • cochlear neuritis;
  • tinnitus;
  • celeri defecation;
  • enterocolitis;
  • intracranial hypertension;
  • the reduction of hemoglobin and platelets;
  • dyspepsia;
  • disorders of the Central nervous system, cardiovascular system;
  • toxic kidney damage.
the refusal to accept alcohol

Why can't you drink alcohol while taking antibiotics?

  1. Observed inactivation or increase the toxicity of drugs.
  2. Toxic metabolites distort the action of antimicrobials.
  3. There is an increase in elimination half-life of ethanol.
  4. Increases the risk of allergic reactions.
  5. Violated the filtration and detoxification functions of the liver.
  6. Slowing the clearance of xenobiotics by the body.

How long can I drink alcohol after taking antibiotics?

After completing antibiotic therapy it is better not to drink alcoholic beverages without consulting your doctor. All the necessary information about how long after taking antibiotics can you drink alcohol, contained in the instructions for medical use of the drug. Read carefully the following items:

  • the duration of treatment;
  • compatibility of drugs with ethanol;
  • section, which indicate how much not to drink after antibiotics.

On average, abstinence from alcoholic beverages lasts from 3 to 7 days.

The length of the period depends on the type of pharmacological means and the speed of its eschrichtii. If in the abstract there is no information about compatibility with ethyl alcohol, refrain from drinking alcohol for at least 24 hours after treatment. In some cases you should refrain from drinking alcohol for at least 72 hours.

06.01.2019